CHEMGRID MOLECULE CARD
Kenpaullone
Kenpaullone in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00998
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00998
- Molecular formula
- BrC16H11N2O
- Libraries
- Lopac
Stored SMILES
Brc1ccc2nc3c(CC(=O)Nc4ccccc43)c2c1Matched external records: PubChem 3820
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CDK9/cyclin T1 | ChEMBL | No stored yeast mapping |
| Glycogen synthase kinase-3 | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| FYN · Tyrosine-protein kinase Fyn | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| GSK3A · Glycogen synthase kinase-3 alpha | ChEMBL | No stored yeast mapping |
| GSK3B · Glycogen synthase kinase-3 beta [CHEMBL262] | ChEMBL | No stored yeast mapping |
| Gsk3b · Glycogen synthase kinase-3 beta [CHEMBL3669] | ChEMBL | No stored yeast mapping |
| NR0B1 · Nuclear receptor subfamily 0 group B member 1 | ChEMBL | No stored yeast mapping |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL | No stored yeast mapping |
| CDK1, CDK2, CDK5 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Kenpaullone research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.