CHEMGRID MOLECULE CARD
NSC 95397
NSC 95397 in ChemGrid: 24 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00971
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00971
- Molecular formula
- C14H14O4S2
- InChIKey
- MAASHDQFQDDECQ-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 2,3-Bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Stored SMILES
OCCSc1c(=O)c2ccccc2c(=O)c1SCCOMatched external records: PubChem 262093
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| tep1-2nd | Lopac | 4932 | -13.42 |
| GAS1 | Lopac | 4932 | -11.96 |
| BY4743 | Lopac | 4932 | -8.26 |
| smi1 | Lopac | 4932 | -5.34 |
| whi5 | Lopac | 4932 | -4.24 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CDC25A · M-phase inducer phosphatase 1 | ChEMBL | YGR203W (ortholog_many2many); MIH1 YMR036C (ortholog_many2many); ARR2 YPR200C (ortholog_many2many) |
| CDC25B · M-phase inducer phosphatase 2 | ChEMBL | YGR203W (ortholog_many2many); ARR2 YPR200C (ortholog_many2many) |
| CDC25C · M-phase inducer phosphatase 3 | ChEMBL | YGR203W (ortholog_many2many); ARR2 YPR200C (ortholog_many2many) |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL | DIT2 YDR402C (ortholog_one2many) |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TGR · Thioredoxin glutathione reductase | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| Cdc25 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete NSC 95397 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.