CHEMGRID MOLECULE CARD
Ibudilast
Ibudilast in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00968
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00968
- Molecular formula
- C14H18N2O
- InChIKey
- ZJVFLBOZORBYFE-UHFFFAOYSA-N
- Libraries
- Lopac
Stored SMILES
CC(C)C(=O)c1c2C=CC=Cn2nc1C(C)CMatched external records: PubChem 3671
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL | DIT2 YDR402C (ortholog_one2many) |
| CYP2D6 · Cytochrome P450 2D6 | ChEMBL | No stored yeast mapping |
| MIF · Macrophage migration inhibitory factor | ChEMBL | No stored yeast mapping |
| PDE3A · cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | ChEMBL | No stored yeast mapping |
| PDE3B · cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | ChEMBL | No stored yeast mapping |
| PDE4A · 3',5'-cyclic-AMP phosphodiesterase 4A | ChEMBL | No stored yeast mapping |
| PDE4B · 3',5'-cyclic-AMP phosphodiesterase 4B | ChEMBL | No stored yeast mapping |
| PDE4C · 3',5'-cyclic-AMP phosphodiesterase 4C | ChEMBL | No stored yeast mapping |
| PDE4D · 3',5'-cyclic-AMP phosphodiesterase 4D | ChEMBL | No stored yeast mapping |
| PDE IV | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Ibudilast research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.