CHEMGRID MOLECULE CARD
4-Hydroxybenzhydrazide
4-Hydroxybenzhydrazide in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00964
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00964
- Molecular formula
- C7H8N2O2
- InChIKey
- ZMZGIVVRBMFZSG-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 4-Hydroxybenzoic acid hydrazide
Stored SMILES
NNC(=O)c1ccc(O)cc1Matched external records: PubChem 1742
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| CTSB · Cathepsin B | ChEMBL | No stored yeast mapping |
| CTSH · Cathepsin H | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| GFER · FAD-linked sulfhydryl oxidase ALR | ChEMBL | ERV1 YGR029W (ortholog_one2one) |
| MPO · Myeloperoxidase | ChEMBL | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| Inhibitor | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4-Hydroxybenzhydrazide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.