CHEMGRID MOLECULE CARD
17alpha-hydroxyprogesterone
17alpha-hydroxyprogesterone in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00951
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00951
- Molecular formula
- C21H30O3
- InChIKey
- DBPWSSGDRRHUNT-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 17alpha-Hydroxypregn-4-ene-3,20-dione
Stored SMILES
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21CMatched external records: PubChem 521928
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| GBA1 · Lysosomal acid glucosylceramidase | ChEMBL analogue | No stored yeast mapping |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL analogue | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL analogue | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL analogue | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL analogue | PIN4 YBL051C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Progesterone | ChemGrid bioactivity_info | No stored yeast mapping |
| ADRA2C · alpha | lopac_target_list | No stored yeast mapping |
| Pgrmc2 · progesterone | lopac_target_list | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 17alpha-hydroxyprogesterone research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.