CHEMGRID MOLECULE CARD
Hydralazine hydrochloride
Hydralazine hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00942
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00942
- Molecular formula
- C8ClH9N4
- InChIKey
- ZUXNZUWOTSUBMN-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Hydralazine Hydrochloride
Stored SMILES
Cl.NNc1nncc2ccccc21Matched external records: PubChem 9351
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ache · Acetylcholinesterase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| BCHE · Cholinesterase | ChEMBL | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| GOT1 · Aspartate aminotransferase, cytoplasmic | ChEMBL | AAT1 YKL106W (ortholog_many2many); AAT2 YLR027C (ortholog_many2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| ache · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| BCHE · Cholinesterase | ChEMBL analogue | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL analogue | SMI1 YGR229C (ortholog_one2many) |
| GOT1 · Aspartate aminotransferase, cytoplasmic | ChEMBL analogue | AAT1 YKL106W (ortholog_many2many); AAT2 YLR027C (ortholog_many2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| TP53 · Cellular tumor antigen p53 | ChEMBL analogue | No stored yeast mapping |
| MAO-A/B | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Hydralazine hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.