CHEMGRID MOLECULE CARD
GW5074
GW5074 in ChemGrid: 24 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00935
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00935
- Molecular formula
- Br2C15H8INO2
- Libraries
- Lopac
- Other recorded names
- GW-5074
Stored SMILES
Oc1c(Br)cc(cc1Br)C=c1c(=O)nc2ccc(I)cc21Matched external records: PubChem 5924208
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| MT2481-pdr1pdr3 | Lopac | 4932 | -51.25 |
| whi5 | Lopac | 4932 | -10.11 |
| Gim3 | Lopac | 4932 | -8.13 |
| BY4743 | Lopac | 4932 | -8.12 |
| smi1 | Lopac | 4932 | -4.28 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APOBEC3G · DNA dC->dU-editing enzyme APOBEC-3G | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| HTT · Huntingtin | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| KIF15 · Kinesin-like protein KIF15 | ChEMBL | No stored yeast mapping |
| MAP1LC3B · Microtubule-associated protein 1 light chain 3 beta | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| PLK4 · Serine/threonine-protein kinase PLK4 | ChEMBL | No stored yeast mapping |
| RAF1 · RAF proto-oncogene serine/threonine-protein kinase | ChEMBL | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL | No stored yeast mapping |
| Raf1 kinase | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete GW5074 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.