CHEMGRID MOLECULE CARD
GW2974
GW2974 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00930
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00930
- Molecular formula
- C23H21N7
- InChIKey
- DYYZXRCFCVDSKD-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- N6,N6-dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine
Stored SMILES
CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1Matched external records: PubChem 6603857
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL | No stored yeast mapping |
| Erbb2 · Receptor tyrosine-protein kinase erbB-2 | ChEMBL | No stored yeast mapping |
| ERBB4 · Receptor tyrosine-protein kinase erbB-4 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| SHMT2 · Serine hydroxymethyltransferase, mitochondrial | ChEMBL | SHM2 YLR058C (ortholog_one2many) |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL analogue | No stored yeast mapping |
| Erbb2 · Receptor tyrosine-protein kinase erbB-2 | ChEMBL analogue | No stored yeast mapping |
| ERBB4 · Receptor tyrosine-protein kinase erbB-4 | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| SHMT2 · Serine hydroxymethyltransferase, mitochondrial | ChEMBL analogue | SHM2 YLR058C (ortholog_one2many) |
| TP53 · Cellular tumor antigen p53 | ChEMBL analogue | No stored yeast mapping |
| EGFR / ErbB-2 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete GW2974 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.