CHEMGRID MOLECULE CARD
beta-Estradiol
beta-Estradiol in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00900
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00900
- Molecular formula
- C18H24O2
- InChIKey
- VOXZDWNPVJITMN-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta(a)phenanthrene-3,17-diol
Stored SMILES
CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OMatched external records: PubChem 450
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AR · Androgen receptor | ChEMBL | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| NR3C1 · Glucocorticoid receptor | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| ampC · Beta-lactamase | ChEMBL analogue | No stored yeast mapping |
| AR · Androgen receptor | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| NR3C1 · Glucocorticoid receptor | ChEMBL analogue | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL analogue | No stored yeast mapping |
| Estrogen | ChemGrid bioactivity_info | No stored yeast mapping |
| ADRBK1 · beta | lopac_target_list | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete beta-Estradiol research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.