CHEMGRID MOLECULE CARD
rac-2-Ethoxy-3-octadecanamido-1-propylphosphocholine
rac-2-Ethoxy-3-octadecanamido-1-propylphosphocholine in ChemGrid: 24 screened assays, 24 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00892
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00892
- Molecular formula
- C28H59N2O6P
- InChIKey
- QUVZKDZYEOYGKV-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- rac-2-Ethoxy-3-octadecanamido-1-propylphosphocholi; 3-Octadecanamido-2-ethoxypropylphosphocholine
Stored SMILES
[O-]P(=O)(OCC[N+](C)(C)C)OCC(CNC(=O)CCCCCCCCCCCCCCCCC)OCCMatched external records: PubChem 72241
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 24 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| SAP30 | Lopac | 4932 | -81.84 |
| CIN2 | Lopac | 4932 | -72.47 |
| MRC1 | Lopac | 4932 | -69.40 |
| NUM1 | Lopac | 4932 | -58.12 |
| MT2481-pdr1pdr3 | Lopac | 4932 | -51.85 |
| SQS1 | Lopac | 4932 | -45.93 |
| GAS1 | Lopac | 4932 | -44.91 |
| NOP16 | Lopac | 4932 | -43.19 |
| NOP13 | Lopac | 4932 | -43.06 |
| HOC1 | Lopac | 4932 | -42.92 |
| Pac10 | Lopac | 4932 | -41.58 |
| KRE1 | Lopac | 4932 | -40.02 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATXN2 · Ataxin-2 | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL analogue | No stored yeast mapping |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| PKC | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete rac-2-Ethoxy-3-octadecanamido-1-propylphosphocholine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.