CHEMGRID MOLECULE CARD
Ebselen
Ebselen in ChemGrid: 24 screened assays, 6 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00890
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00890
- Molecular formula
- C13H9NOSe
- InChIKey
- DYEFUKCXAQOFHX-UHFFFAOYSA-N
- Libraries
- Lopac
Stored SMILES
O=C1N([Se]c2ccccc12)c1ccccc1Matched external records: PubChem 3194
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 6 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| MT2481-pdr1pdr3 | Lopac | 4932 | -52.31 |
| whi5 | Lopac | 4932 | -27.93 |
| Gim3 | Lopac | 4932 | -19.26 |
| Tep1 | Lopac | 4932 | -13.20 |
| SQS1 | Lopac | 4932 | -8.55 |
| HOC1 | Lopac | 4932 | -5.62 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| blaNDM-1 · Metallo-beta-lactamase type 2 | ChEMBL | No stored yeast mapping |
| gag · Structural capsid protein | ChEMBL | No stored yeast mapping |
| GALE · UDP-glucose 4-epimerase | ChEMBL | GAL10 YBR019C (ortholog_one2one) |
| HDAC2 · Histone deacetylase 2 | ChEMBL | No stored yeast mapping |
| IDE · Insulin-degrading enzyme | ChEMBL | No stored yeast mapping |
| lef · Lethal factor | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| tcdB · Toxin B | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| blaNDM-1 · Metallo-beta-lactamase type 2 | ChEMBL analogue | No stored yeast mapping |
| gag · Structural capsid protein | ChEMBL analogue | No stored yeast mapping |
| GALE · UDP-glucose 4-epimerase | ChEMBL analogue | GAL10 YBR019C (ortholog_one2one) |
| HDAC2 · Histone deacetylase 2 | ChEMBL analogue | No stored yeast mapping |
| IDE · Insulin-degrading enzyme | ChEMBL analogue | No stored yeast mapping |
| lef · Lethal factor | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL analogue | No stored yeast mapping |
| tcdB · Toxin B | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| . | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Ebselen research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.