CHEMGRID MOLECULE CARD
7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in ChemGrid: 24 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00880
Explore activity & SONAR![Chemical structure of 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine](/structure-thumbnails/Lopac/LO/LOPAC_00880.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- LOPAC 00880
- Molecular formula
- C23H22N4O
- InChIKey
- FMETVQKSDIOGPX-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d; 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamine
Stored SMILES
Nc1ncnc2n(cc(c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1Matched external records: PubChem 6603792
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| MT2481-pdr1pdr3 | Lopac | 4932 | -47.00 |
| Gim3 | Lopac | 4932 | -4.32 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BTK · Tyrosine-protein kinase BTK | ChEMBL | No stored yeast mapping |
| EGFR · Epidermal growth factor receptor | ChEMBL | No stored yeast mapping |
| FYN · Tyrosine-protein kinase Fyn | ChEMBL | No stored yeast mapping |
| KDR · Vascular endothelial growth factor receptor 2 | ChEMBL | No stored yeast mapping |
| LCK · Tyrosine-protein kinase Lck | ChEMBL | No stored yeast mapping |
| LYN · Tyrosine-protein kinase Lyn | ChEMBL | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL | No stored yeast mapping |
| SRC · Proto-oncogene tyrosine-protein kinase Src | ChEMBL | No stored yeast mapping |
| TEK · Angiopoietin-1 receptor | ChEMBL | No stored yeast mapping |
| BTK · Tyrosine-protein kinase BTK | ChEMBL analogue | No stored yeast mapping |
| EGFR · Epidermal growth factor receptor | ChEMBL analogue | No stored yeast mapping |
| FYN · Tyrosine-protein kinase Fyn | ChEMBL analogue | No stored yeast mapping |
| KDR · Vascular endothelial growth factor receptor 2 | ChEMBL analogue | No stored yeast mapping |
| LCK · Tyrosine-protein kinase Lck | ChEMBL analogue | No stored yeast mapping |
| LYN · Tyrosine-protein kinase Lyn | ChEMBL analogue | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL analogue | No stored yeast mapping |
| SRC · Proto-oncogene tyrosine-protein kinase Src | ChEMBL analogue | No stored yeast mapping |
| TEK · Angiopoietin-1 receptor | ChEMBL analogue | No stored yeast mapping |
| Ick | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.