CHEMGRID MOLECULE CARD
5,5-Diphenylhydantoin
5,5-Diphenylhydantoin in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00835
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00835
- Molecular formula
- C15H12N2O2
- InChIKey
- CXOFVDLJLONNDW-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Phenytoin
Stored SMILES
OC1NC(C(=O)N=1)(c1ccccc1)c1ccccc1Matched external records: PubChem 1775
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| FEN1 · Flap endonuclease 1 | ChEMBL | RAD27 YKL113C (ortholog_one2one) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| GLA · Alpha-galactosidase A | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| KMT2A · Histone-lysine N-methyltransferase 2A | ChEMBL analogue | No stored yeast mapping |
| lef · Lethal factor | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
| Anticonvulsant; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5,5-Diphenylhydantoin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.