CHEMGRID MOLECULE CARD
Cantharidin
Cantharidin in ChemGrid: 24 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00793
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00793
- Molecular formula
- C10H12O4
- InChIKey
- DHZBEENLJMYSHQ-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Stored SMILES
CC12C3CCC(O3)C1(C)C(=O)OC2=OMatched external records: PubChem 2545
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| NOP13 | Lopac | 4932 | -5.32 |
| BY4741 | Lopac | 4932 | -4.92 |
| whi3 | Lopac | 4932 | -4.80 |
| whi5 | Lopac | 4932 | -4.50 |
| SQS1 | Lopac | 4932 | -4.46 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APP · Amyloid-beta precursor protein | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL | No stored yeast mapping |
| Serine-threonine protein phosphatase 2A regulatory subunit | ChEMBL analogue | No stored yeast mapping |
| APP · Amyloid-beta precursor protein | ChEMBL analogue | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PPM1B · Protein phosphatase 1B | ChEMBL analogue | PTC5 YOR090C (ortholog_one2many) |
| PPP1CA · Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | ChEMBL analogue | PPZ1 YML016C (ortholog_one2many) |
| PPP1CC · Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | ChEMBL analogue | PPZ1 YML016C (ortholog_one2many) |
| PPP5C · Serine/threonine-protein phosphatase | ChEMBL analogue | PPT1 YGR123C (ortholog_one2one) |
| PPP5C · Serine/threonine-protein phosphatase 5 | ChEMBL analogue | PPT1 YGR123C (ortholog_one2one) |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL analogue | No stored yeast mapping |
| TFPI2 · Tissue factor pathway inhibitor 2 | ChEMBL analogue | No stored yeast mapping |
| PP2A | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Cantharidin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.