CHEMGRID MOLECULE CARD
Chelerythrine chloride
Chelerythrine chloride in ChemGrid: 24 screened assays, 18 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00762
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00762
- Molecular formula
- C21ClH19NO4
- Libraries
- Lopac
- Other recorded names
- Chelerythrine, chloride
Stored SMILES
[ClH-].COc1ccc2c(c[n+](C)c3c2ccc2cc4OCOc4cc23)c1OCMatched external records: PubChem 72311
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 18 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| CIN2 | Lopac | 4932 | -64.01 |
| NUM1 | Lopac | 4932 | -56.24 |
| HOC1 | Lopac | 4932 | -42.68 |
| GAS1 | Lopac | 4932 | -41.69 |
| KRE1 | Lopac | 4932 | -39.84 |
| SQS1 | Lopac | 4932 | -37.26 |
| dep1 | Lopac | 4932 | -34.18 |
| LGE1 | Lopac | 4932 | -31.21 |
| Tep1 | Lopac | 4932 | -29.53 |
| ESC2 | Lopac | 4932 | -26.70 |
| smi1 | Lopac | 4932 | -25.79 |
| whi5 | Lopac | 4932 | -25.16 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL analogue | SMI1 YGR229C (ortholog_one2many) |
| FEN1 · Flap endonuclease 1 | ChEMBL analogue | RAD27 YKL113C (ortholog_one2one) |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL analogue | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| VDR · Vitamin D3 receptor | ChEMBL analogue | No stored yeast mapping |
| PKC | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Chelerythrine chloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.