CHEMGRID MOLECULE CARD

Corticosterone

Corticosterone in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LOPAC 00759

Explore activity & SONAR

Chemical structure of Corticosterone — Stored molecular structure

24Screened assays

0Significant assay responses

6Source-labelled target records

Identity and chemistry

ChemGrid identifier: LOPAC 00759
Molecular formula: C21H30O4
InChIKey: OMFXVFTZEKFJBZ-UHFFFAOYSA-N
Libraries: Lopac
Other recorded names: Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-

Stored SMILES

CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO

Matched external records: PubChem 439739

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Luciferin 4-monooxygenase	ChEMBL analogue	No stored yeast mapping
ERG · Transcriptional regulator ERG	ChEMBL analogue	No stored yeast mapping
NFE2L2 · Nuclear factor erythroid 2-related factor 2	ChEMBL analogue	No stored yeast mapping
rep · Replicase polyprotein 1ab	ChEMBL analogue	No stored yeast mapping
TDP1 · Tyrosyl-DNA phosphodiesterase 1	ChEMBL analogue	TDP1 YBR223C (ortholog_one2one)
Glucocorticoid	ChemGrid bioactivity_info	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Corticosterone research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.