CHEMGRID MOLECULE CARD
SB 202190
SB 202190 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00723
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00723
- Molecular formula
- C20FH14N3O
- Libraries
- Lopac
- Other recorded names
- Sb-202190
Stored SMILES
Oc1ccc(cc1)c1nc(c2ccc(F)cc2)c(n1)c1ccncc1Matched external records: PubChem 5169
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Large T antigen | ChEMBL | No stored yeast mapping |
| MAP kinase p38 | ChEMBL | No stored yeast mapping |
| ALOX5 · Polyunsaturated fatty acid 5-lipoxygenase | ChEMBL | No stored yeast mapping |
| CSNK1D · Casein kinase I isoform delta | ChEMBL | YCK3 YER123W (ortholog_many2many); YCK1 YHR135C (ortholog_many2many); YCK2 YNL154C (ortholog_many2many) |
| GAK · Cyclin-G-associated kinase | ChEMBL | No stored yeast mapping |
| GCGR · Glucagon receptor | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| MAPK10 · Mitogen-activated protein kinase 10 | ChEMBL | No stored yeast mapping |
| MAPK11 · Mitogen-activated protein kinase 11 | ChEMBL | No stored yeast mapping |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| NLK · Serine/threonine-protein kinase NLK | ChEMBL | No stored yeast mapping |
| Tyr · Tyrosinase | ChEMBL | No stored yeast mapping |
| p38 MAPK | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete SB 202190 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.