CHEMGRID MOLECULE CARD
3-Bromo-7-nitroindazole
3-Bromo-7-nitroindazole in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00709
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00709
- Molecular formula
- BrC7H4N3O2
- Libraries
- Lopac
- Other recorded names
- 3-Bromo-7-Nitroindazole
Stored SMILES
[O-][N+](=O)c1cccc2c(Br)nnc21Matched external records: PubChem 1649
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| Nos1 · Nitric oxide synthase 1 [CHEMBL3048] | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| NOS1 · Nitric oxide synthase 1 [CHEMBL3568] | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| Nos2 · Nitric oxide synthase, inducible [CHEMBL3051] | ChEMBL | No stored yeast mapping |
| Nos2 · Nitric oxide synthase, inducible [CHEMBL3464] | ChEMBL | No stored yeast mapping |
| NOS2 · Nitric oxide synthase, inducible [CHEMBL4481] | ChEMBL | No stored yeast mapping |
| NOS3 · Nitric oxide synthase 3 | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| NOS | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-Bromo-7-nitroindazole research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.