CHEMGRID MOLECULE CARD
ATPO
ATPO in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00686
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00686
- Molecular formula
- C11H19N2O7P
- InChIKey
- AGSOOCUNMTYPSE-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 2-Amino-3-(5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl)propanoic acid
Stored SMILES
CC(C)(C)c1onc(OCP(O)(O)=O)c1CC(N)C(O)=OMatched external records: PubChem 4615193
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cruzipain | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| FEN1 · Flap endonuclease 1 | ChEMBL | RAD27 YKL113C (ortholog_one2one) |
| Gria2 · Glutamate receptor ionotropic, AMPA | ChEMBL | No stored yeast mapping |
| Grik1 · Glutamate receptor ionotropic, kainate | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate NMDA receptor | ChEMBL | No stored yeast mapping |
| PIN1 · Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | ChEMBL | ESS1 YJR017C (ortholog_one2one) |
| GluR1-4 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ATPO research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.