CHEMGRID MOLECULE CARD
5-(N-Ethyl-N-isopropyl)amiloride
5-(N-Ethyl-N-isopropyl)amiloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00665
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00665
- Molecular formula
- C11ClH18N7O
- InChIKey
- QDERNBXNXJCIQK-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Eipa
Stored SMILES
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)N=C(N)NMatched external records: PubChem 1795
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| SLC9A1 · Sodium/hydrogen exchanger 1 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| SLC9A2 · Sodium/hydrogen exchanger 2 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| Slc9a3 · Sodium/hydrogen exchanger 3 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| SLC9A5 · Sodium/hydrogen exchanger 5 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL | PPN1 YDR452W (ortholog_one2many) |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| ATXN2 · Ataxin-2 | ChEMBL analogue | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL analogue | No stored yeast mapping |
| RAD52 · DNA repair protein RAD52 homolog | ChEMBL analogue | RAD59 YDL059C (ortholog_one2many); RAD52 YML032C (ortholog_one2many) |
| SLC9A1 · Sodium/hydrogen exchanger 1 | ChEMBL analogue | NHX1 YDR456W (ortholog_one2many) |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL analogue | PPN1 YDR452W (ortholog_one2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| THPO · Thrombopoietin | ChEMBL analogue | No stored yeast mapping |
| Na+/H+ Antiporter | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5-(N-Ethyl-N-isopropyl)amiloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.