CHEMGRID MOLECULE CARD
Reserpine
Reserpine in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00649
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00649
- Molecular formula
- C33H40N2O9
- Libraries
- Lopac
Stored SMILES
COC1C(CC2CN3CCc4c(nc5cc(OC)ccc54)C3CC2C1C(=O)OC)OC(=O)c1cc(OC)c(OC)c(OC)c1Matched external records: PubChem 5770
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ABCB1 · ATP-dependent translocase ABCB1 | ChEMBL | MDL1 YLR188W (ortholog_many2many); MDL2 YPL270W (ortholog_many2many) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| PDE3A · cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | ChEMBL | No stored yeast mapping |
| PDE4A · 3',5'-cyclic-AMP phosphodiesterase 4A | ChEMBL | No stored yeast mapping |
| SLC18A1 · Chromaffin granule amine transporter | ChEMBL | No stored yeast mapping |
| SLC18A2 · Synaptic vesicular amine transporter [CHEMBL1893] | ChEMBL | TPO2 YGR138C (ortholog_many2many); TPO3 YPR156C (ortholog_many2many) |
| SLC18A2 · Synaptic vesicular amine transporter [CHEMBL4271] | ChEMBL | TPO2 YGR138C (ortholog_many2many); TPO3 YPR156C (ortholog_many2many) |
| Slc18a2 · Synaptic vesicular amine transporter [CHEMBL4295886] | ChEMBL | TPO2 YGR138C (ortholog_many2many); TPO3 YPR156C (ortholog_many2many) |
| Slc18a2 · Synaptic vesicular amine transporter [CHEMBL4828] | ChEMBL | TPO2 YGR138C (ortholog_many2many); TPO3 YPR156C (ortholog_many2many) |
| Uptake | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Reserpine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.