CHEMGRID MOLECULE CARD
Diacylglycerol kinase inhibitor I
Diacylglycerol kinase inhibitor I in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00586
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00586
- Molecular formula
- C27FH26N3OS
- InChIKey
- MFVJXLPANKSLLD-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- R 59022
Stored SMILES
CC1N=C2SC=CN2C(=O)C=1CCN1CCC(CC1)=C(c1ccccc1)c1ccc(F)cc1Matched external records: PubChem 3012
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| DGKA · Diacylglycerol kinase alpha | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL | RAD27 YKL113C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| lef · Lethal factor | ChEMBL | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| TSHR · Thyrotropin receptor | ChEMBL | No stored yeast mapping |
| Drd2 · D(2) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| HRH1 · Histamine H1 receptor | ChEMBL analogue | PRP22 YER013W (ortholog_one2one) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| Htr2b · Serotonin 2 (5-HT2) receptor | ChEMBL analogue | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL analogue | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL analogue | No stored yeast mapping |
| PKM · Pyruvate kinase PKM | ChEMBL analogue | CDC19 YAL038W (ortholog_many2many); PYK2 YOR347C (ortholog_many2many) |
| Diacylglycerol kinase | ChemGrid bioactivity_info | No stored yeast mapping |
| DGKA · Diacylglycerol kinase | lopac_target_list | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Diacylglycerol kinase inhibitor I research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.