CHEMGRID MOLECULE CARD
DL-alpha-Methyl-p-tyrosine
DL-alpha-Methyl-p-tyrosine in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00581
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00581
- Molecular formula
- C10H13NO3
- InChIKey
- NHTGHBARYWONDQ-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- alpha-Methyl-p-tyrosine
Stored SMILES
CC(N)(Cc1ccc(O)cc1)C(O)=OMatched external records: PubChem 3125
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cruzipain | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| PIN1 · Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | ChEMBL | ESS1 YJR017C (ortholog_one2one) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| PIN1 · Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | ChEMBL analogue | ESS1 YJR017C (ortholog_one2one) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL analogue | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL analogue | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL analogue | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Tyrosine hydroxylase | ChemGrid bioactivity_info | No stored yeast mapping |
| ADRA2C · alpha | lopac_target_list | No stored yeast mapping |
| ROR2 · Tyrosine | lopac_target_list | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DL-alpha-Methyl-p-tyrosine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.