CHEMGRID MOLECULE CARD
Ritanserin
Ritanserin in ChemGrid: 24 screened assays, 3 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00535
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00535
- Molecular formula
- C27F2H25N3OS
- InChIKey
- JUQLTPCYUFPYKE-UHFFFAOYSA-N
- Libraries
- Lopac
Stored SMILES
CC1N=C2SC=CN2C(=O)C=1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1Matched external records: PubChem 5074
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 3 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| NOP13 | Lopac | 4932 | 12.91 |
| NOP16 | Lopac | 4932 | 10.03 |
| BY4741 | Lopac | 4932 | 4.91 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Drd2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| HRH1 · Histamine H1 receptor | ChEMBL | PRP22 YER013W (ortholog_one2one) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| Htr2b · Serotonin 2 (5-HT2) receptor | ChEMBL | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL | No stored yeast mapping |
| PKM · Pyruvate kinase PKM | ChEMBL | CDC19 YAL038W (ortholog_many2many); PYK2 YOR347C (ortholog_many2many) |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| DGKA · Diacylglycerol kinase alpha | ChEMBL analogue | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| Drd2 · D(2) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL analogue | RAD27 YKL113C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| HRH1 · Histamine H1 receptor | ChEMBL analogue | PRP22 YER013W (ortholog_one2one) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| Htr2b · Serotonin 2 (5-HT2) receptor | ChEMBL analogue | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL analogue | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| lef · Lethal factor | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PKM · Pyruvate kinase PKM | ChEMBL analogue | CDC19 YAL038W (ortholog_many2many); PYK2 YOR347C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| TSHR · Thyrotropin receptor | ChEMBL analogue | No stored yeast mapping |
| 5-HT2/5-HT1C | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Ritanserin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.