CHEMGRID MOLECULE CARD

IC 261

IC 261 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LOPAC 00529

Explore activity & SONAR

Chemical structure of IC 261 — Stored molecular structure

24Screened assays

0Significant assay responses

9Source-labelled target records

Identity and chemistry

ChemGrid identifier: LOPAC 00529
Molecular formula: C18H17NO4
Libraries: Lopac
Other recorded names: IC261

Stored SMILES

COc1cc(OC)c(C=c2c(=O)nc3ccccc32)c(OC)c1

Matched external records: PubChem 5288600

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
ATAD5 · ATPase family AAA domain-containing protein 5	ChEMBL	No stored yeast mapping
CBX1 · Chromobox protein homolog 1	ChEMBL	No stored yeast mapping
CSNK1D · Casein kinase I isoform delta	ChEMBL	YCK3 YER123W (ortholog_many2many); YCK1 YHR135C (ortholog_many2many); YCK2 YNL154C (ortholog_many2many)
CSNK1E · Casein kinase I isoform epsilon	ChEMBL	No stored yeast mapping
CYP1A2 · Cytochrome P450 1A2	ChEMBL	No stored yeast mapping
CYP2C9 · Cytochrome P450 2C9	ChEMBL	No stored yeast mapping
CYP3A4 · Cytochrome P450 3A4	ChEMBL	No stored yeast mapping
MPHOSPH8 · M-phase phosphoprotein 8	ChEMBL	No stored yeast mapping
CK-1delta/epsilon	ChemGrid bioactivity_info	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete IC 261 research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.