CHEMGRID MOLECULE CARD
Fluoxetine hydrochloride
Fluoxetine hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00510
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00510
- Molecular formula
- C17ClF3H19NO
- InChIKey
- GIYXAJPCNFJEHY-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Reconcile
Stored SMILES
Cl.CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1Matched external records: PubChem 62857
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CX3CR1 · CX3C chemokine receptor 1 | ChEMBL | No stored yeast mapping |
| GPR65 · G-protein coupled receptor 65 | ChEMBL | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| Slc6a2 · Transporter | ChEMBL | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| UBE2N · Ubiquitin-conjugating enzyme E2 N | ChEMBL | No stored yeast mapping |
| CX3CR1 · CX3C chemokine receptor 1 | ChEMBL analogue | No stored yeast mapping |
| GPR65 · G-protein coupled receptor 65 | ChEMBL analogue | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL analogue | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| Slc6a2 · Transporter | ChEMBL analogue | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter | ChEMBL analogue | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter | ChEMBL analogue | No stored yeast mapping |
| UBE2N · Ubiquitin-conjugating enzyme E2 N | ChEMBL analogue | No stored yeast mapping |
| Reuptake | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Fluoxetine hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.