CHEMGRID MOLECULE CARD
Loperamide hydrochloride
Loperamide hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00444
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00444
- Molecular formula
- C29Cl2H34N2O2
- InChIKey
- PGYPOBZJRVSMDS-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Loperamide Hydrochloride
Stored SMILES
Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1Matched external records: PubChem 71420
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| C5AR1 · C5a anaphylatoxin chemotactic receptor 1 | ChEMBL | No stored yeast mapping |
| GPR119 · Glucose-dependent insulinotropic receptor | ChEMBL | No stored yeast mapping |
| GPR35 · G-protein coupled receptor 35 | ChEMBL | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| OPRD1 · Delta-type opioid receptor | ChEMBL | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| OPRM1 · Mu-type opioid receptor | ChEMBL | No stored yeast mapping |
| SIGMAR1 · Sigma non-opioid intracellular receptor 1 | ChEMBL | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| TMEM97 · Sigma intracellular receptor 2 | ChEMBL | YLR050C (ortholog_one2one) |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| C5AR1 · C5a anaphylatoxin chemotactic receptor 1 | ChEMBL analogue | No stored yeast mapping |
| GPR119 · Glucose-dependent insulinotropic receptor | ChEMBL analogue | No stored yeast mapping |
| GPR35 · G-protein coupled receptor 35 | ChEMBL analogue | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL analogue | No stored yeast mapping |
| OPRD1 · Delta-type opioid receptor | ChEMBL analogue | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL analogue | No stored yeast mapping |
| OPRM1 · Mu-type opioid receptor | ChEMBL analogue | No stored yeast mapping |
| SIGMAR1 · Sigma non-opioid intracellular receptor 1 | ChEMBL analogue | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter | ChEMBL analogue | No stored yeast mapping |
| TMEM97 · Sigma intracellular receptor 2 | ChEMBL analogue | YLR050C (ortholog_one2one) |
| Ligand | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Loperamide hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.