CHEMGRID MOLECULE CARD
ICI 204,448 hydrochloride
ICI 204,448 hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00440
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00440
- Molecular formula
- C23Cl3H27N2O4
- InChIKey
- FNDGLVOYAQNQPE-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 2-(3-(1-((2-(3,4-Dichlorophenyl)acetyl)methylamino)-2-(1-pyrrolidinyl)ethyl)phenoxy)acetic acid hydrochloride (1:1)
Stored SMILES
Cl.CN(C(CN1CCCC1)c1cccc(OCC(O)=O)c1)C(=O)Cc1ccc(Cl)c(Cl)c1Matched external records: PubChem 129407
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| CHRM5 · Muscarinic acetylcholine receptor M5 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| ERG · Transcriptional regulator ERG | ChEMBL | No stored yeast mapping |
| HTR5A · 5-hydroxytryptamine receptor 5A | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| OPRD1 · Delta-type opioid receptor | ChEMBL | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| OPRM1 · Mu-type opioid receptor | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| kappa | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ICI 204,448 hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.