CHEMGRID MOLECULE CARD
Calmidazolium chloride
Calmidazolium chloride in ChemGrid: 24 screened assays, 22 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00418
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00418
- Molecular formula
- C31Cl7H24N2O
- Libraries
- Lopac
- Other recorded names
- Calmidazolium Chloride
Stored SMILES
[ClH-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1Matched external records: PubChem 644274
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 22 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| SAP30 | Lopac | 4932 | -81.68 |
| CIN2 | Lopac | 4932 | -72.42 |
| MRC1 | Lopac | 4932 | -69.35 |
| NUM1 | Lopac | 4932 | -58.15 |
| MT2481-pdr1pdr3 | Lopac | 4932 | -52.52 |
| SQS1 | Lopac | 4932 | -46.64 |
| GAS1 | Lopac | 4932 | -44.83 |
| NOP13 | Lopac | 4932 | -44.05 |
| Pac10 | Lopac | 4932 | -42.95 |
| HOC1 | Lopac | 4932 | -42.94 |
| KRE1 | Lopac | 4932 | -40.22 |
| dep1 | Lopac | 4932 | -38.42 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| GroEL/GroES | ChEMBL | No stored yeast mapping |
| ATP2A1 · Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | ChEMBL | ENA5 YDR038C (ortholog_many2many); ENA2 YDR039C (ortholog_many2many); ENA1 YDR040C (ortholog_many2many); CCC2 YDR270W (ortholog_many2many); PMA1 YGL008C (ortholog_many2many); PMR1 YGL167C (ortholog_many2many); PMA2 YPL036W (ortholog_many2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| IDE · Insulin-degrading enzyme | ChEMBL | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| SUMO1 · Small ubiquitin-related modifier 1 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| TMPRSS15 · Enteropeptidase | ChEMBL | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
| Ca2+ATPase | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Calmidazolium chloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.