CHEMGRID MOLECULE CARD
6,7-Dichloroquinoxaline-2,3-dione
6,7-Dichloroquinoxaline-2,3-dione in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00359
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00359
- Molecular formula
- C8Cl2H4N2O2
- InChIKey
- AVBSIKMUAFYZAV-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 2,3-Dihydroxy-6,7-dichloroquinoxaline
Stored SMILES
Clc1cc2NC(=O)C(=O)Nc2cc1ClMatched external records: PubChem 1845
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATXN2 · Ataxin-2 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| FTO · Alpha-ketoglutarate-dependent dioxygenase FTO | ChEMBL | No stored yeast mapping |
| GBA1 · Lysosomal acid glucosylceramidase | ChEMBL | No stored yeast mapping |
| Gria2 · Glutamate receptor ionotropic, AMPA | ChEMBL | No stored yeast mapping |
| GRIN1 · Glutamate [NMDA] receptor | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate NMDA receptor | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate receptor ionotropic, NMDA 1 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| NMDA-glycine | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 6,7-Dichloroquinoxaline-2,3-dione research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.