CHEMGRID MOLECULE CARD
DNQX
DNQX in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00357
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00357
- Molecular formula
- C8H4N4O6
- InChIKey
- RWVIMCIPOAXUDG-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Dnqx
Stored SMILES
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=OMatched external records: PubChem 3899541
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GBA1 · Lysosomal acid glucosylceramidase | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| Gria2 · Glutamate receptor ionotropic, AMPA | ChEMBL | No stored yeast mapping |
| GRIA4 · Glutamate receptor ionotropic AMPA | ChEMBL | No stored yeast mapping |
| GRIK1 · Glutamate receptor ionotropic kainate | ChEMBL | No stored yeast mapping |
| Grik1 · Glutamate receptor ionotropic, kainate | ChEMBL | No stored yeast mapping |
| GRIN1 · Glutamate [NMDA] receptor | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate NMDA receptor | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| Kainate/quisqualate | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DNQX research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.