CHEMGRID MOLECULE CARD
(±)-6-Chloro-PB hydrobromide
(±)-6-Chloro-PB hydrobromide in ChemGrid: 24 screened assays, 4 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00309
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00309
- Molecular formula
- BrC16ClH17NO2
- InChIKey
- RMIJGBMRNYUZRG-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- (±)-6-Chloro-PB hydrobromide; (+-)-6-Chloro-PB hydrobromide
Stored SMILES
Br.Oc1cc2C(CNCCc2c(Cl)c1O)c1ccccc1Matched external records: PubChem 11957706
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 4 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| LGE1 | Lopac | 4932 | -14.74 |
| smi1 | Lopac | 4932 | -6.00 |
| HOC1 | Lopac | 4932 | -5.74 |
| NUM1 | Lopac | 4932 | -4.62 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Large T antigen | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL | No stored yeast mapping |
| Htr2a · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| OPRM1 · Mu-type opioid receptor | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ampC · Beta-lactamase | ChEMBL analogue | No stored yeast mapping |
| ATXN2 · Ataxin-2 | ChEMBL analogue | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| FTL · Ferritin light chain | ChEMBL analogue | No stored yeast mapping |
| GAA · Lysosomal alpha-glucosidase | ChEMBL analogue | ROT2 YBR229C (ortholog_one2many) |
| GLA · Alpha-galactosidase A | ChEMBL analogue | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| Htr2a · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
First 30 of 39 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete (±)-6-Chloro-PB hydrobromide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.