CHEMGRID MOLECULE CARD

(6R)-5,6,7,8-Tetrahydro-L-biopterin hydrochloride

(6R)-5,6,7,8-Tetrahydro-L-biopterin hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LOPAC 00295

Explore activity & SONAR

Chemical structure of (6R)-5,6,7,8-Tetrahydro-L-biopterin hydrochloride — Stored molecular structure

24Screened assays

0Significant assay responses

4Source-labelled target records

Identity and chemistry

ChemGrid identifier: LOPAC 00295
Molecular formula: C9Cl2H17N5O3
InChIKey: RKSUYBCOVNCALL-UHFFFAOYSA-N
Libraries: Lopac
Other recorded names: Sapropterin Dihydrochloride;Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride

Stored SMILES

Cl.Cl.CC(O)C(O)C1CNC2N=C(N)NC(=O)C=2N1

Matched external records: PubChem 135889530

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Pah · Phenylalanine-4-hydroxylase	ChEMBL	No stored yeast mapping
TH · Tyrosine 3-monooxygenase	ChEMBL	No stored yeast mapping
Tph1 · Tryptophan 5-hydroxylase 1	ChEMBL	No stored yeast mapping
Tyrosine	ChemGrid bioactivity_info	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete (6R)-5,6,7,8-Tetrahydro-L-biopterin hydrochloride research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.