CHEMGRID MOLECULE CARD
JL-18
JL-18 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00288
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00288
- Molecular formula
- C18H21N5
- InChIKey
- MMCMKWDIEUZMQB-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine
Stored SMILES
CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(C)cc21Matched external records: PubChem 3802
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adra1b · Adrenergic receptor alpha-1 | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| Drd2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD4 · D(4) dopamine receptor | ChEMBL | No stored yeast mapping |
| Htr2a · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| Htr2b · Serotonin 2 (5-HT2) receptor | ChEMBL | No stored yeast mapping |
| TSG101 · Tumor susceptibility gene 101 protein | ChEMBL | STP22 YCL008C (ortholog_one2many) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| D4>D2 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete JL-18 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.