CHEMGRID MOLECULE CARD
Dihydroergotamine methanesulfonate
Dihydroergotamine methanesulfonate in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00279
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00279
- Molecular formula
- C34H41N5O8S
- Libraries
- Lopac
- Other recorded names
- Dihydroergotamine Mesylate
Stored SMILES
CN1CC(CC2C1Cc1cnc3cccc2c13)C(=O)NC1(C)OC2(O)C3CCCN3C(=O)C(Cc3ccccc3)N2C1=O.CS(O)(=O)=OMatched external records: PubChem 71171
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2B · Alpha-2B adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2C · Alpha-2C adrenergic receptor | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD4 · D(4) dopamine receptor | ChEMBL | No stored yeast mapping |
| HTR1A · 5-hydroxytryptamine receptor 1A | ChEMBL | No stored yeast mapping |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| HTR5A · 5-hydroxytryptamine receptor 5A | ChEMBL | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL | No stored yeast mapping |
| Antagonist | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Dihydroergotamine methanesulfonate research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.