CHEMGRID MOLECULE CARD
Dihydroergocristine methanesulfonate
Dihydroergocristine methanesulfonate in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00278
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00278
- Molecular formula
- C36H45N5O8S
- Libraries
- Lopac
- Other recorded names
- Dihydroergocristine Mesylate
Stored SMILES
CC(C)C1(NC(=O)C2CC3C(Cc4cnc5cccc3c45)N(C)C2)OC2(O)C3CCCN3C(=O)C(Cc3ccccc3)N2C1=O.CS(O)(=O)=OMatched external records: PubChem 444034
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adra1a · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| Adra1b · Alpha-1B adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA1D · Alpha-1D adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2B · Alpha-2B adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2C · Alpha-2C adrenergic receptor | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL | No stored yeast mapping |
| Htr1a · 5-hydroxytryptamine receptor 1A | ChEMBL | No stored yeast mapping |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| Agonist | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Dihydroergocristine methanesulfonate research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.