CHEMGRID MOLECULE CARD
GBR-12909 dihydrochloride
GBR-12909 dihydrochloride in ChemGrid: 24 screened assays, 11 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00275
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00275
- Molecular formula
- C28Cl2F2H34N2O
- InChIKey
- MIBSKSYCRFWIRU-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Vanoxerine dihydrochloride
Stored SMILES
Cl.Cl.Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1Matched external records: PubChem 104920
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 11 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| smi1 | Lopac | 4932 | -24.78 |
| LGE1 | Lopac | 4932 | -14.33 |
| NUM1 | Lopac | 4932 | -13.45 |
| KRE1 | Lopac | 4932 | -12.68 |
| HOC1 | Lopac | 4932 | -9.51 |
| MRC1 | Lopac | 4932 | -8.71 |
| Gim3 | Lopac | 4932 | -7.22 |
| CIN2 | Lopac | 4932 | -6.77 |
| Pac10 | Lopac | 4932 | -6.00 |
| dep1 | Lopac | 4932 | -4.91 |
| ESC2 | Lopac | 4932 | -4.65 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| Slc6a2 · Norepinephrine transporter | ChEMBL | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL | No stored yeast mapping |
| Slc6a2 · Transporter | ChEMBL | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL analogue | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| Reuptake | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete GBR-12909 dihydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.