CHEMGRID MOLECULE CARD
(±)-SKF-38393 hydrochloride
(±)-SKF-38393 hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00273
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00273
- Molecular formula
- C16ClH18NO2
- InChIKey
- YEWHJCLOUYPAOH-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- (±)-SKF-38393 hydrochloride; SKF-38393 hydrochloride
Stored SMILES
Cl.Oc1cc2CCNCC(c3ccccc3)c2cc1OMatched external records: PubChem 147514
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adcy1 · Adenylate cyclase | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GFER · FAD-linked sulfhydryl oxidase ALR | ChEMBL | ERV1 YGR029W (ortholog_one2one) |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| KDM4C · Lysine-specific demethylase 4C | ChEMBL | No stored yeast mapping |
| pos-1 · RNA-binding protein pos-1 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| DRD3 · D(3) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| Htr2a · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| OPRM1 · Mu-type opioid receptor | ChEMBL analogue | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| D1 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete (±)-SKF-38393 hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.