CHEMGRID MOLECULE CARD
4-Hydroxyphenethylamine hydrochloride
4-Hydroxyphenethylamine hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00260
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00260
- Molecular formula
- C8ClH12NO
- InChIKey
- RNISDHSYKZAWOK-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Tyramine hydrochloride
Stored SMILES
Cl.NCCc1ccc(O)cc1Matched external records: PubChem 66449
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| TyR1 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| KMT2A · Histone-lysine N-methyltransferase 2A | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL analogue | No stored yeast mapping |
| HTR1A · 5-hydroxytryptamine receptor 1A | ChEMBL analogue | No stored yeast mapping |
| Htr2b · 5-hydroxytryptamine receptor 2B | ChEMBL analogue | No stored yeast mapping |
| Htr3a · Serotonin (5-HT) receptor | ChEMBL analogue | No stored yeast mapping |
| L3MBTL1 · Lethal(3)malignant brain tumor-like protein 1 | ChEMBL analogue | No stored yeast mapping |
| Taar1 · Trace amine-associated receptor 1 | ChEMBL analogue | No stored yeast mapping |
| Agonist | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4-Hydroxyphenethylamine hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.