CHEMGRID MOLECULE CARD
Mecamylamine hydrochloride
Mecamylamine hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00207
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00207
- Molecular formula
- C11ClH22N
- InChIKey
- PKVZBNCYEICAQP-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Mecamylamine Hydrochloride
Stored SMILES
Cl.CNC1(C)C2CCC(C2)C1(C)CMatched external records: PubChem 13221
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| MBD4 · Methyl-CpG-binding domain protein 4 | ChEMBL | No stored yeast mapping |
| MPG · DNA-3-methyladenine glycosylase | ChEMBL | No stored yeast mapping |
| MUTYH · Adenine DNA glycosylase | ChEMBL | No stored yeast mapping |
| NEIL1 · Endonuclease 8-like 1 | ChEMBL | No stored yeast mapping |
| NEIL2 · Endonuclease 8-like 2 | ChEMBL | No stored yeast mapping |
| NTHL1 · Endonuclease III-like protein 1 | ChEMBL | NTG2 YOL043C (ortholog_one2one) |
| OGG1 · N-glycosylase/DNA lyase | ChEMBL | MAG1 YER142C (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| SMUG1 · Single-strand selective monofunctional uracil DNA glycosylase | ChEMBL | No stored yeast mapping |
| TDG · G/T mismatch-specific thymine DNA glycosylase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| Chrna4 · Neuronal acetylcholine receptor; alpha4/beta2 | ChEMBL analogue | No stored yeast mapping |
| Chrna7 · Neuronal acetylcholine receptor subunit alpha-7 | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| MBD4 · Methyl-CpG-binding domain protein 4 | ChEMBL analogue | No stored yeast mapping |
| MPG · DNA-3-methyladenine glycosylase | ChEMBL analogue | No stored yeast mapping |
| MUTYH · Adenine DNA glycosylase | ChEMBL analogue | No stored yeast mapping |
| NEIL1 · Endonuclease 8-like 1 | ChEMBL analogue | No stored yeast mapping |
| NEIL2 · Endonuclease 8-like 2 | ChEMBL analogue | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| NTHL1 · Endonuclease III-like protein 1 | ChEMBL analogue | NTG2 YOL043C (ortholog_one2one) |
| OGG1 · N-glycosylase/DNA lyase | ChEMBL analogue | MAG1 YER142C (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| SMUG1 · Single-strand selective monofunctional uracil DNA glycosylase | ChEMBL analogue | No stored yeast mapping |
| TDG · G/T mismatch-specific thymine DNA glycosylase | ChEMBL analogue | No stored yeast mapping |
| Nicotinic | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Mecamylamine hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.