CHEMGRID MOLECULE CARD
McN-A-343
McN-A-343 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00181
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00181
- Molecular formula
- C14Cl2H19N2O2
- Libraries
- Lopac
- Other recorded names
- 4-((((3-Chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-2-butyn-1-aminium chloride (1:1)
Stored SMILES
[ClH-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1Matched external records: PubChem 5926
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Muscarinic acetylcholine receptor | ChEMBL | No stored yeast mapping |
| CHRM1 · Muscarinic acetylcholine receptor M1 [CHEMBL216] | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 [CHEMBL276] | ChEMBL | No stored yeast mapping |
| CHRM2 · Muscarinic acetylcholine receptor M2 | ChEMBL | No stored yeast mapping |
| CHRM3 · Muscarinic acetylcholine receptor M3 [CHEMBL245] | ChEMBL | No stored yeast mapping |
| CHRM4 · Muscarinic acetylcholine receptor M4 | ChEMBL | No stored yeast mapping |
| CHRM5 · Muscarinic acetylcholine receptor M5 | ChEMBL | No stored yeast mapping |
| GPM3 · Muscarinic acetylcholine receptor M3 [CHEMBL5498] | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| M1 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete McN-A-343 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.