CHEMGRID MOLECULE CARD
UK 14,304
UK 14,304 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00159
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00159
- Molecular formula
- BrC11H10N5
- InChIKey
- XYLJNLCSTIOKRM-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Brimonidine
Stored SMILES
Brc1c(NC2NCCN=2)ccc2nccnc12Matched external records: PubChem 2435
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Alpha-1B adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| Adra1b · Adrenergic receptor alpha-1 | ChEMBL | No stored yeast mapping |
| ADRA1D · Alpha-1D adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| Adra2b · Alpha-2B adrenergic receptor | ChEMBL | No stored yeast mapping |
| Adra2c · Adrenergic receptor alpha-2 | ChEMBL | No stored yeast mapping |
| ADRA2C · Alpha-2C adrenergic receptor | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| alpha2 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete UK 14,304 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.