CHEMGRID MOLECULE CARD
Prazosin hydrochloride
Prazosin hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00137
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00137
- Molecular formula
- C19ClH21N5O4
- Libraries
- Lopac
- Other recorded names
- Prazosin Hydrochloride
Stored SMILES
Cl.COc1cc2nc(nc(N)c2cc1OC)N1CCN(=CC1)C(=O)c1occc1Matched external records: PubChem 68546
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adrenergic receptor alpha-1 | ChEMBL | No stored yeast mapping |
| ADRA1A · Alpha-1A adrenergic receptor [CHEMBL229] | ChEMBL | No stored yeast mapping |
| Adra1a · Alpha-1A adrenergic receptor [CHEMBL319] | ChEMBL | No stored yeast mapping |
| ADRA1B · Alpha-1B adrenergic receptor [CHEMBL232] | ChEMBL | No stored yeast mapping |
| Adra1b · Alpha-1B adrenergic receptor [CHEMBL315] | ChEMBL | No stored yeast mapping |
| ADRA2B · Alpha-2B adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2C · Alpha-2C adrenergic receptor | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| HTR5A · 5-hydroxytryptamine receptor 5A | ChEMBL | No stored yeast mapping |
| TSPO · Translocator protein | ChEMBL | No stored yeast mapping |
| alpha1 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Check the interactive profile for current structural prediction availability.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Prazosin hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.