CHEMGRID MOLECULE CARD
p-Aminoclonidine hydrochloride
p-Aminoclonidine hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00087
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00087
- Molecular formula
- C9Cl3H11N4
- InChIKey
- OTQYGBJVDRBCHC-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- Apraclonidine Hydrochloride
Stored SMILES
Cl.Nc1cc(Cl)c(N=C2NCCN2)c(Cl)c1Matched external records: PubChem 51763
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GBA1 · Lysosomal acid glucosylceramidase | ChEMBL | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ADRA1B · Alpha-1B adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ADRA1D · Alpha-1D adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ADRA2B · Alpha-2B adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| ADRA2C · Alpha-2C adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| HTR7 · 5-hydroxytryptamine receptor 7 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| TMEM97 · Sigma intracellular receptor 2 | ChEMBL analogue | YLR050C (ortholog_one2one) |
| alpha2 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete p-Aminoclonidine hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.