CHEMGRID MOLECULE CARD
CGS-15943
CGS-15943 in ChemGrid: 24 screened assays, 13 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00034
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00034
- Molecular formula
- C13ClH8N5O
- InChIKey
- MSJODEOZODDVGW-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 9-Chloro-2-(2-furanyl)(1,2,4)triazolo(1,5-c)quinazolin-5-amine
Stored SMILES
NC1=Nc2ccc(Cl)cc2c2nc(nn12)c1occc1Matched external records: PubChem 2690
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 13 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| Pac10 | Lopac | 4932 | -23.24 |
| BY4743 | Lopac | 4932 | -19.94 |
| whi5 | Lopac | 4932 | -15.92 |
| NOP13 | Lopac | 4932 | -15.73 |
| Tep1 | Lopac | 4932 | -14.92 |
| Gim3 | Lopac | 4932 | -13.65 |
| SQS1 | Lopac | 4932 | -13.43 |
| BY4741 | Lopac | 4932 | -13.20 |
| NOP16 | Lopac | 4932 | -11.97 |
| MT2481-pdr1pdr3 | Lopac | 4932 | -10.28 |
| Cln3 | Lopac | 4932 | -9.20 |
| whi3 | Lopac | 4932 | -7.02 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA1 · Adenosine receptor A1 | ChEMBL | No stored yeast mapping |
| Adora2a · Adenosine receptor A2a | ChEMBL | No stored yeast mapping |
| Adora2b · Adenosine A2 receptor | ChEMBL | No stored yeast mapping |
| ADORA2B · Adenosine receptor A2b | ChEMBL | No stored yeast mapping |
| ADORA3 · Adenosine receptor A3 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| PIK3CG · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ChEMBL | No stored yeast mapping |
| PRKDC · DNA-dependent protein kinase catalytic subunit | ChEMBL | No stored yeast mapping |
| A1 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CGS-15943 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.