CHEMGRID MOLECULE CARD
Chlorpropamide
Chlorpropamide in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00030
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00030
- Molecular formula
- C10ClH13N2O3S
- InChIKey
- RKWGIWYCVPQPMF-UHFFFAOYSA-N
- Libraries
- Lopac
Stored SMILES
CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1Matched external records: PubChem 2727
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| ERG · Transcriptional regulator ERG | ChEMBL | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL | RAD27 YKL113C (ortholog_one2one) |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| ERG · Transcriptional regulator ERG | ChEMBL analogue | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL analogue | RAD27 YKL113C (ortholog_one2one) |
| FTL · Ferritin light chain | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL analogue | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Insulin | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Chlorpropamide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.