CHEMGRID MOLECULE CARD
L-732,138
L-732,138 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 00017
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 00017
- Molecular formula
- C22F6H18N2O3
- Libraries
- Lopac
Stored SMILES
CC(=O)NC(Cc1cnc2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)FMatched external records: PubChem 132837
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| TACR1 · Substance-P receptor [CHEMBL249] | ChEMBL | No stored yeast mapping |
| Tacr1 · Substance-P receptor [CHEMBL4027] | ChEMBL | No stored yeast mapping |
| TACR2 · Substance-K receptor [CHEMBL2327] | ChEMBL | No stored yeast mapping |
| TACR2 · Substance-K receptor [CHEMBL3433] | ChEMBL | No stored yeast mapping |
| Tacr2 · Substance-K receptor [CHEMBL4554] | ChEMBL | No stored yeast mapping |
| Tacr3 · Neuromedin-K receptor [CHEMBL3154] | ChEMBL | No stored yeast mapping |
| TACR3 · Neuromedin-K receptor [CHEMBL4429] | ChEMBL | No stored yeast mapping |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
| NK1 > NK2, NK3 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete L-732,138 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.