CHEMGRID MOLECULE CARD
Novel
Novel in ChemGrid: 5 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT024H11
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT024H11
- Molecular formula
- C16H10N2O3
- InChIKey
- WDKQLYHQNBQDHB-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- N'-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)benzohydrazide
Stored SMILES
O=C(NN=C1C(=O)c2ccccc2C1=O)c1ccccc1Matched external records: PubChem 871656
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| wt18h | LATCA | 4932 | -9.63 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ABL1 · Ras and Rab interactor 1/Tyrosine-protein kinase ABL1 | ChEMBL | No stored yeast mapping |
| APAF1 · Apoptotic protease-activating factor 1 | ChEMBL | No stored yeast mapping |
| CASP3 · Caspase-3 | ChEMBL | No stored yeast mapping |
| dnaB · Replicative DNA helicase DnaB | ChEMBL | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| SENP8 · Sentrin-specific protease 8 | ChEMBL | No stored yeast mapping |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Novel research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.