CHEMGRID MOLECULE CARD
S001 C04
S001 C04 in ChemGrid: 5 screened assays, 3 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT024H08
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT024H08
- Molecular formula
- Br2C13H13NO2S2
- InChIKey
- YHASDVHEIVBFTJ-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- 2-(3,5-Dibromo-2-hydroxyphenyl)-2-oxoethyl pyrrolidine-1-carbodithioate
Stored SMILES
Oc1c(Br)cc(Br)cc1C(=O)CSC(=S)N1CCCC1Matched external records: PubChem 1246365
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 3 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| wt18h | LATCA | 4932 | -17.73 |
| pdr18h | LATCA | 4932 | -10.89 |
| pdr22h | LATCA | 4932 | -6.13 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| CGA · Glycoprotein hormones alpha chain | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| ERG · Transcriptional regulator ERG | ChEMBL | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| HTT · Huntingtin | ChEMBL | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
| WRN · Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete S001 C04 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.