CHEMGRID MOLECULE CARD

Novel

Novel in ChemGrid: 5 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LAT023B03

Explore activity & SONAR

Chemical structure of Novel — Stored molecular structure

5Screened assays

1Significant assay responses

11Source-labelled target records

Identity and chemistry

ChemGrid identifier: LAT023B03
Molecular formula: C15H16N2O3
InChIKey: FRUVMUVSFMLXIO-UHFFFAOYSA-N
Libraries: LATCA
Other recorded names: N-(2-methoxybenzyl)-2-methyl-4-nitroaniline

Stored SMILES

[O-][N+](=O)c1ccc(NCc2ccccc2OC)c(C)c1

Matched external records: PubChem 2850014

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

5 measurements across 5 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
wt18h	LATCA	4932	-5.46

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
ALDH1A1 · Aldehyde dehydrogenase 1A1	ChEMBL	ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many)
ATXN2 · Ataxin-2	ChEMBL	No stored yeast mapping
BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B	ChEMBL	BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many)
FTL · Ferritin light chain	ChEMBL	No stored yeast mapping
MAPT · Microtubule-associated protein tau	ChEMBL	No stored yeast mapping
MEN1 · Menin/Histone-lysine N-methyltransferase MLL	ChEMBL	No stored yeast mapping
NFE2L2 · Nuclear factor erythroid 2-related factor 2	ChEMBL	No stored yeast mapping
POLH · DNA polymerase eta	ChEMBL	RAD30 YDR419W (ortholog_one2one)
POLI · DNA polymerase iota	ChEMBL	No stored yeast mapping
PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor	ChEMBL	No stored yeast mapping
TDP1 · Tyrosyl-DNA phosphodiesterase 1	ChEMBL	TDP1 YBR223C (ortholog_one2one)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Novel research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.